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  • 22.10.2017
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Antibiotic pancreas penetration

The use of antibiotics in acute pancreatitis despite recent clinical trials remains controversial. The aim of this study is to review the latest clinical trials and guidelines about antibiotics in acute pancreatitis and determine its proper use. Through a Medline search, we selected and analyzed pertinent randomized clinical trials and guidelines that evaluated the use of antibiotics in acute pancreatitis. We answered the most frequent questions about this topic. In these patients, AP develops in two phases: the first ten days are characterized by the systemic inflammatory response syndrome SIRS , whereas in the end of the second week infection complications begin to appear [ 2 ]. The mechanisms of infection in AP are bacteria translocation, via lymphatic, via hematogenic, and reflux from duodenum and biliary tree as well [ 7 ]. If the major problem in AP is infection of pancreatic necrosis, it makes sense to consider that the use of antibiotics in this situation could reduce the morbidity and mortality of these patients.
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Efficacy of antibiotic penetration into pancreatic necrosis

Antibiotic pancreas penetration
Antibiotic pancreas penetration
Antibiotic pancreas penetration
Antibiotic pancreas penetration
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Efficacy of antibiotic penetration into pancreatic necrosis

Background: Infection of pancreatic necrosis is the most dangerous complication of acute necrotizing pancreatitis. Infection is undoubtedly caused by the endogenous flora of the host. This is why prophylaxis with a broad-spectrum antibiotic is considered an effective procedure. However, two aspects should be taken into consideration when choosing the antibiotic; it should have the spectrum of action consistent with the pathogens and it should penetrate effectively to the necrotic tissue of the pancreas.
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Questions about the use of antibiotics in acute pancreatitis

Background: Infection of pancreatic necrosis is the most dangerous complication of acute necrotizing pancreatitis. Infection is undoubtedly caused by the endogenous flora of the host. This is why prophylaxis with a broad-spectrum antibiotic is considered an effective procedure. However, two aspects should be taken into consideration when choosing the antibiotic; it should have the spectrum of action consistent with the pathogens and it should penetrate effectively to the necrotic tissue of the pancreas. Patients and methods: Necrotic tissue of the pancreas and the inflammatory ascites surrounding the pancreas were derived from 15 patients male, 10; female, 5; mean age 46 years , who underwent laparatomy due to pancreatic necrosis after treatment for 14—21 days.
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